Allanal 24 10 30 Aviana Violet And: Nicole Aria

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Nicole Aria

3. Content Planning

4.2. Synthesis of Allanal 24‑10‑30

  1. Step 1 – N‑alkylation (Scheme 1): 4‑bromo‑2‑nitro‑anisole (10 mmol) was coupled with 1‑(4‑methoxyphenyl)‑pyrrolidine (12 mmol) under Buchwald‑Hartwig conditions (Pd₂(dba)₃, XPhos, 110 °C, 12 h).
  2. Step 2 – Nitro‑reduction: The crude product was reduced using Fe/HCl (excess) at 80 °C, affording the corresponding aniline (85 % yield).
  3. Step 3 – Cyclisation: Intramolecular cyclisation was induced with POCl₃ (5 eq) to generate the fused heterocycle Allanal 24‑10‑30 (78 % isolated yield).

Purity was verified by analytical HPLC (≥98 %).

Spectroscopic data:

10. Follow-Up

Aviana Violet

8. Contingency Planning